Brian R Curtis Selected Research

Neonatal Alloimmune Thrombocytopenia

2/2020	Strategies to develop a prophylaxis for the prevention of HPA-1a immunization and fetal and neonatal alloimmune thrombocytopenia.
11/2019	Bioengineered iPSC-derived megakaryocytes for the detection of platelet-specific patient alloantibodies.
11/2018	High-resolution mapping of the polyclonal immune response to the human platelet alloantigen HPA-1a (PlA1).
1/2017	Severe neonatal alloimmune thrombocytopenia caused by maternal sensitization against a new low-frequency alloantigen (Domb ) located on platelet glycoprotein IIIa.
2/2016	CRISPR/Cas9-mediated conversion of human platelet alloantigen allotypes.
6/2015	A new low-frequency alloantigen (Kha(b) ) located on platelet glycoprotein IIIa as a cause of maternal sensitization leading to neonatal alloimmune thrombocytopenia.
5/2014	Low-frequency human platelet antigens as triggers for neonatal alloimmune thrombocytopenia.
6/2013	Prevalence and clinical significance of low-avidity HPA-1a antibodies in women exposed to HPA-1a during pregnancy.
4/2013	Neonatal alloimmune thrombocytopenia: pathogenesis, diagnosis and management.
5/2012	New platelet glycoprotein polymorphisms causing maternal immunization and neonatal alloimmune thrombocytopenia.

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Brian R Curtis Research Topics

Disease

38	Thrombocytopenia (Thrombopenia) 01/2022 - 03/2002
14	Neonatal Alloimmune Thrombocytopenia 02/2020 - 08/2004
12	Hemorrhage 01/2022 - 08/2004
12	Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune) 01/2022 - 09/2004
9	Neutropenia 01/2019 - 05/2004
9	Transfusion-Related Acute Lung Injury 12/2014 - 05/2006
6	Thrombosis (Thrombus) 01/2020 - 09/2004
5	Transfusion Reaction 11/2018 - 09/2002
4	Neoplasms (Cancer) 03/2014 - 03/2006
2	Immune System Diseases (Immune Disorders) 01/2022 - 01/2020
2	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 09/2020 - 12/2010
2	Colonic Neoplasms (Colon Cancer) 03/2014 - 03/2006
2	Agranulocytosis (Granulocytopenia) 01/2014 - 03/2010
2	Colorectal Neoplasms (Colorectal Cancer) 03/2010 - 10/2009
2	Sepsis (Septicemia) 01/2010 - 07/2004
1	Agammaglobulinemia (Hypogammaglobulinemia) 01/2022
1	Venous Thrombosis (Deep-Vein Thrombosis) 01/2021
1	Anemia 09/2020
1	Hematologic Neoplasms (Hematological Malignancy) 09/2020
1	Disease Progression 01/2020
1	Polyneuropathies (Polyneuropathy) 01/2020
1	Transthyretin-Related Hereditary Amyloidosis 01/2020
1	Myocardial Infarction 01/2020
1	Aplastic Anemia (Anemia, Hypoplastic) 12/2019
1	Platelet Glycoprotein IV Deficiency 12/2019
1	Pulmonary Embolism 10/2017
1	Thromboembolism 01/2017
1	Hemolytic-Uremic Syndrome 05/2015
1	Thrombotic Thrombocytopenic Purpura 05/2015
1	Thrombotic Microangiopathies 05/2015
1	Drug-Related Side Effects and Adverse Reactions 05/2015
1	Nausea 10/2014
1	Febrile Neutropenia 10/2014
1	Colitis 10/2014
1	Cellulitis 10/2014
1	Thrombocytopenia chromosome breakage 01/2014

Drug/Important Bio-Agent (IBA)

39	AntibodiesIBA 01/2022 - 03/2002
20	Pharmaceutical PreparationsIBA 01/2022 - 03/2002
9	Heparin (Liquaemin)FDA LinkGeneric 01/2022 - 01/2003
7	Isoantigens (Alloantigen)IBA 01/2018 - 08/2004
7	AntigensIBA 11/2012 - 05/2006
6	Oxaliplatin (Eloxatin)FDA LinkGeneric 01/2018 - 03/2006
4	Immunoglobulin G (IgG)IBA 01/2022 - 03/2002
4	Platelet Membrane GlycoproteinsIBA 11/2019 - 03/2006
4	Human Platelet AntigensIBA 11/2018 - 08/2004
4	Anti-Bacterial Agents (Antibiotics)IBA 01/2014 - 07/2004
3	Glycoproteins (Glycoprotein)IBA 09/2020 - 09/2002
3	Eptifibatide (Integrilin)FDA Link 01/2020 - 09/2002
3	Platelet Factor 4IBA 10/2017 - 01/2015
3	Integrin beta3 (GPIIIa)IBA 01/2017 - 03/2006
3	Member 2 Protein Solute Carrier Family 44IBA 12/2014 - 03/2010
3	Platinum Compounds (Compounds, Platinum)IBA 03/2014 - 10/2009
3	Biological ProductsIBA 06/2012 - 02/2007
3	LipidsIBA 06/2012 - 09/2007
3	AutoantibodiesIBA 09/2004 - 05/2004
2	VaccinesIBA 01/2022 - 12/2013
2	human ITGB3 protein (HPA-1a)IBA 02/2020 - 01/2018
2	Intravenous Immunoglobulins (IVIG)FDA Link 12/2019 - 01/2017
2	Serotonin (5 Hydroxytryptamine)IBA 10/2017 - 10/2013
2	Vancomycin FDA LinkGeneric 01/2014 - 03/2007
2	Levamisole (Decaris)FDA Link 01/2014 - 03/2010
2	Dacarbazine (DIC)FDA LinkGeneric 01/2010 - 10/2009
2	Leucovorin (Folinic Acid)FDA Link 10/2009 - 03/2006
2	Fluorouracil (Carac)FDA LinkGeneric 10/2009 - 03/2006
2	IsoantibodiesIBA 09/2008 - 08/2004
1	Peptide Hydrolases (Proteases)FDA Link 01/2022
1	EnzymesIBA 01/2022
1	Inosine Triphosphate (ITP)IBA 01/2022
1	Ad26COVS1IBA 01/2021
1	Trastuzumab (Herceptin)FDA Link 01/2021
1	Antisense OligonucleotidesIBA 01/2020
1	InotersenIBA 01/2020
1	Rituximab (Mabthera)FDA Link 12/2019
1	Micafungin (FK463)FDA Link 01/2019
1	4- ((1,4,8,11- tetraazacyclotetradec- 1- yl)methyl)benzoic acidIBA 10/2017
1	AnticoagulantsIBA 01/2017
1	Immunoglobulins (Immunoglobulin)IBA 01/2016
1	thiamine triphosphorate (TTP)IBA 05/2015
1	Sulfamethoxazole Drug Combination Trimethoprim (Co-Trimoxazole)FDA LinkGeneric 05/2015
1	Irinotecan (Camptosar)FDA LinkGeneric 02/2014
1	Membrane Glycoproteins (Membrane Glycoprotein)IBA 01/2014
1	LactamsIBA 01/2014
1	Propylthiouracil FDA Link 01/2014
1	Dipyrone (Metamizole)IBA 01/2014
1	Calcium DobesilateIBA 01/2014
1	Carbamazepine (Tegretol)FDA LinkGeneric 01/2014
1	Diclofenac (SR 38)FDA LinkGeneric 01/2014
1	Spironolactone (Aldactone)FDA LinkGeneric 01/2014
1	Sulfamethoxazole FDA LinkGeneric 01/2014
1	Clozapine (Clozaril)FDA LinkGeneric 01/2014
1	Antithyroid Agents (Antithyroid Drugs)IBA 01/2014
1	Ticlopidine (Ticlid)FDA LinkGeneric 01/2014
1	Trimethoprim (Proloprim)FDA LinkGeneric 01/2014

Therapy/Procedure

5	Therapeutics 10/2017 - 05/2010
4	Drug Therapy (Chemotherapy) 12/2017 - 03/2006
3	Platelet Transfusion (Blood Platelet Transfusions) 09/2020 - 09/2002
2	Aftercare (After-Treatment) 10/2013 - 09/2002
1	Induction Chemotherapy 09/2020
1	Liver Transplantation 01/2018
1	Subcutaneous Injections 10/2014